Left Atrial Appendage Thrombus Formation in a Patient on Dabigatran Therapy Associated With ABCB1 and CES-1 Genetic Defect

Left Atrial Appendage Thrombus Formation in a Patient on Dabigatran Therapy Associated With ABCB1 and CES-1 Genetic Defect

Dabigatran, directly targeting thrombin, is widely used for the prevention of stroke in nonvalvular atrial fibrillation (NVAF). We reported a rare case of left atrial appendage thrombus formation in a persistent NVAF patient despite the 31 months uninterrupted treatment with dabigatran 110 mg twice...

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Bibliographic Details
Main Authors: Zhi-Chun Gu, Xiao-Wei Ma, Xiao-Yuan Zheng, Long Shen, Fang-Hong Shi, Hao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
dabigatran
left atrial appendage thrombus
genetic polymorphism
ABCB1
CES-1
drug-drug interaction
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00491/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00491/full

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