RNA methylation, homologous recombination repair and therapeutic resistance

RNA methylation, homologous recombination repair and therapeutic resistance

Homologous recombination (HR) repair of DNA double-strand breaks (DSBs) is critical for maintaining genomic integrity and stability. Defects in HR increase the risk of tumorigenesis. However, many human tumors exhibit enhanced HR repair capabilities, consequently endowing tumor cells with resistance...

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Bibliographic Details
Main Authors: Yu Bai, Hanlin Zhao, Haijun Liu, Wei Wang, Hongming Dong, Chenghai Zhao
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Homologous recombination
Double-strand breaks
RNA methylation
Therapeutic resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223012076

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http://www.sciencedirect.com/science/article/pii/S0753332223012076

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