LRP5-Mediated Lipid Uptake Modulates Osteogenic Differentiation of Bone Marrow Mesenchymal Stromal Cells

LRP5-Mediated Lipid Uptake Modulates Osteogenic Differentiation of Bone Marrow Mesenchymal Stromal Cells

Nutritional microenvironment determines the specification of progenitor cells, and lipid availability was found to modulate osteogenesis in skeletal progenitors. Here, we investigated the implications of lipid scarcity in the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs...

Full description

Bibliographic Details
Main Authors: Jiachen Lin, Zhifa Zheng, Jieying Liu, Guihua Yang, Ling Leng, Hai Wang, Guixing Qiu, Zhihong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
bone marrow mesenchymal stromal cell (BMSC)
low-density lipoprotein receptor-related protein 5 (LRP5)
osteogenic differentiation
lipid metabolism
conditional knockout mice
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.766815/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.766815/full

Similar Items