Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct

Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs). Here, we study CD4+ TILs in human lung and colorectal cancers and observe that non-Treg CD4+ TILs average more than 70% of tota...

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Bibliographic Details
Main Authors: Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S.W. Tan, Yannick Simoni, Evan W. Newell
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
cd4
cd8
cd39
til
hcmv
cancer
tumor
infiltrating
bystander
Online Access:http://dx.doi.org/10.1080/2162402X.2021.2012961

Internet

http://dx.doi.org/10.1080/2162402X.2021.2012961

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