An Improved Model for Circular RNA Overexpression: Using the Actin Intron Reveals High Circularization Efficiency

An Improved Model for Circular RNA Overexpression: Using the Actin Intron Reveals High Circularization Efficiency

Abstract Traditionally, the group 1 intron of the T4 td gene is used to generate a foreign circular sequence. However, the T4 system has been shown to be fairly inefficient in expressing circular RNA (circRNA). Here, a new method is developed to express circular sequences with high circularization e...

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Bibliographic Details
Main Authors: Feiya Li, Juanjuan Lyu, Yang Yang, Qiwei Yang, Cristian Santos, Burton B. Yang
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Genetics
Subjects:
actin intron
circRNA
circular RNA
overexpression
splicing factor
T4 intron
Online Access:https://doi.org/10.1002/ggn2.202200019

Internet

https://doi.org/10.1002/ggn2.202200019

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