A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model

A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model

Abstract Pre-erythrocytic malaria vaccines that induce high-titer, durable antibody responses can potentially provide protection from infection. Here, we engineered a virus-like particle (VLP)-based vaccine targeting a recently described vulnerable epitope at the N-terminus of the central repeat reg...

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Bibliographic Details
Main Authors: Lucie Jelínková, Yevel Flores-Garcia, Sarah Shapiro, Bryce T. Roberts, Nikolai Petrovsky, Fidel Zavala, Bryce Chackerian
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00457-1

Internet

https://doi.org/10.1038/s41541-022-00457-1

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