The Application of Adaptive Model Predictive Control for Fed-Batch <i>Escherichia coli</i> BL21 (DE3) Cultivation and Biosynthesis of Recombinant Proteins

The Application of Adaptive Model Predictive Control for Fed-Batch <i>Escherichia coli</i> BL21 (DE3) Cultivation and Biosynthesis of Recombinant Proteins

A model predictive control (MPC) method was investigated as a route to optimize and control the growth of <i>E. coli</i> BL21 (DE3) and biosynthesis of two different recombinant proteins (nerve growth factor NGF and coat protein of bacteriophage Qβ (Qβ-CP)). To determine the target traje...

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Bibliographic Details
Main Authors: Konstantins Dubencovs, Arturs Suleiko, Elina Sile, Ivars Petrovskis, Inara Akopjana, Anastasija Suleiko, Vytautas Galvanauskas, Kaspars Tars, Juris Vanags
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Fermentation
Subjects:
model predictive control (MPC)
fed-batch fermentation
<i>E. coli</i>
recombinant protein
Online Access:https://www.mdpi.com/2311-5637/9/12/1015

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https://www.mdpi.com/2311-5637/9/12/1015

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