Macrophage TGF-β signaling is critical for wound healing with heterotopic ossification after trauma

Macrophage TGF-β signaling is critical for wound healing with heterotopic ossification after trauma

Transforming growth factor–β1 (TGF-β1) plays a central role in normal and aberrant wound healing, but the precise mechanism in the local environment remains elusive. Here, using a mouse model of aberrant wound healing resulting in heterotopic ossification (HO) after traumatic injury, we find autocri...

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Bibliographic Details
Main Authors: Nicole K. Patel, Johanna H. Nunez, Michael Sorkin, Simone Marini, Chase A. Pagani, Amy L. Strong, Charles D. Hwang, Shuli Li, Karthik R. Padmanabhan, Ravi Kumar, Alec C. Bancroft, Joey A. Greenstein, Reagan Nelson, Husain A. Rasheed, Nicholas Livingston, Kaetlin Vasquez, Amanda K. Huber, Benjamin Levi
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-10-01
Series:JCI Insight
Subjects:
Bone biology
Immunology
Online Access:https://doi.org/10.1172/jci.insight.144925

Internet

https://doi.org/10.1172/jci.insight.144925

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