P2Y2 Receptor Promotes High-Fat Diet-Induced Obesity

P2Y2 Receptor Promotes High-Fat Diet-Induced Obesity

P2Y2, a G protein-coupled receptor (R), is expressed in all organs involved in the development of obesity and insulin resistance. To explore the role of it in diet-induced obesity, we fed male P2Y2-R whole body knockout (KO) and wild type (WT) mice (B6D2 genetic background) with regular diet (CNT; 1...

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Bibliographic Details
Main Authors: Yue Zhang, Carolyn M. Ecelbarger, Lisa A. Lesniewski, Christa E. Müller, Bellamkonda K. Kishore
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Endocrinology
Subjects:
purinergic signaling
obesity
adipose tissue
AR-C 118925
insulin resistance
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00341/full

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https://www.frontiersin.org/article/10.3389/fendo.2020.00341/full

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