In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA

In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA

Lipid Nanoparticles (LNPs) are a leading class of mRNA delivery systems. LNPs are made of an ionizable lipid, a polyethyleneglycol (PEG)-lipid conjugate and helper lipids. The success of LNPs is due to proprietary ionizable lipids and appropriate helper lipids. Using a benchmark lipid (D-Lin-MC3) we...

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Bibliographic Details
Main Authors: Ayoub Medjmedj, Albert Ngalle-Loth, Rudy Clemençon, Josef Hamacek, Chantal Pichon, Federico Perche
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Nanomaterials
Subjects:
mRNA therapy
intracellular trafficking
LNP
Online Access:https://www.mdpi.com/2079-4991/12/14/2446

Internet

https://www.mdpi.com/2079-4991/12/14/2446

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