Retrospective analysis of metabolite patterns of clobazam and N-desmethylclobazam in human plasma by LC-MS/MS

Introduction: Clobazam is a benzodiazepine drug, used to treat Lennox-Gastaut syndrome in patients aged 2 years and older. Objective: To support patient care, our laboratory developed a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantification of clobazam (CLB) and its...

Full description

Bibliographic Details
Main Authors: Amol O. Bajaj, Diane Ly, Kamisha L. Johnson-Davis
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Journal of Mass Spectrometry and Advances in the Clinical Lab
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667145X2200013X