Nintedanib downregulates the transition of cultured systemic sclerosis fibrocytes into myofibroblasts and their pro-fibrotic activity

Nintedanib downregulates the transition of cultured systemic sclerosis fibrocytes into myofibroblasts and their pro-fibrotic activity

Abstract Background Circulating fibrocytes are an important source of fibroblasts and myofibroblasts, which are involved in fibrotic processes, including systemic sclerosis (SSc). The study aimed to investigate the effect of nintedanib (a tyrosine kinase inhibitor) in inhibiting the in vitro transit...

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Bibliographic Details
Main Authors: Maurizio Cutolo, Emanuele Gotelli, Paola Montagna, Samuele Tardito, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Stefano Soldano
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Arthritis Research & Therapy
Subjects:
Fibrocytes
Fibrosis
Tyrosine kinase inhibitor
Systemic sclerosis
Online Access:https://doi.org/10.1186/s13075-021-02555-2

Internet

https://doi.org/10.1186/s13075-021-02555-2

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