Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations

Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations

Abstract Background Gastric ulcers represent a worldwide health problem, characterized by erosions that affect the mucous membrane of the stomach and may even reach the muscular layer, leading to serious complications. Numerous natural products have been assessed as anti-ulcerogenic agents, and have...

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Bibliographic Details
Main Authors: Dalia H. Abu-Baih, Alshymaa Abdel-Rahman Gomaa, Nada Mohamed Abdel-Wahab, Enas Reda Abdelaleem, Azza M. Abdel Zaher, Noha F. Hassan, Gerhard Bringmann, Usama Ramadan Abdelmohsen, Faisal H. Altemani, Naseh A. Algehainy, Fatma Alzahraa Mokhtar, Miada F. Abdelwahab
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Apium graveolens L.
Gastric ulcer
Metabolomic profiling
Network pharmacology
Inflammatory cytokines
Online Access:https://doi.org/10.1186/s12906-023-04333-w

Internet

https://doi.org/10.1186/s12906-023-04333-w

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