Identification of the Candidate mGlu2 Allosteric Modulator THRX-195518 through In Silico Method and Evaluation of Its Neuroprotective Potential against Glutamate-Induced Neurotoxicity in SH-SY5Y Cell Line

Identification of the Candidate mGlu2 Allosteric Modulator THRX-195518 through In Silico Method and Evaluation of Its Neuroprotective Potential against Glutamate-Induced Neurotoxicity in SH-SY5Y Cell Line

Glutamate (Glu) toxicity has been an important research topic in toxicology and neuroscience studies. In vitro and in vivo studies have shown that Group II metabotropic Glu2 (mGlu2) activators have cell viability effects. This study aims to determine a candidate ligand with high mGlu2 allosteric reg...

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Bibliographic Details
Main Authors: Fadime Canbolat, Nigar Kantarci-Carsibasi, Sevim Isik, Suhair Rami Mohammed Shamshir, Münteha Girgin
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Current Issues in Molecular Biology
Subjects:
metabotropic glutamate receptor
cell viability
SH-SY5Y
positive allosteric modulator
Online Access:https://www.mdpi.com/1467-3045/46/1/51

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https://www.mdpi.com/1467-3045/46/1/51

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