The effect of genetic variants in the transcription factor TSPYL family on the CYP3A4 mediated cyclosporine metabolism in kidney transplant patients

The effect of genetic variants in the transcription factor TSPYL family on the CYP3A4 mediated cyclosporine metabolism in kidney transplant patients

Abstract CYP3A4 activity shows considerable interindividual variability. Although studies indicate 60%–80% is heritable, common single nucleotide variants (SNVs) in CYP3A4 together only explain ~10%. Transcriptional factors, such as the testis‐specific Y‐encoded‐like proteins (TSPYLs) family, have b...

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Bibliographic Details
Main Authors: Qinglian Zhai, Dirk Jan A. R. Moes, Teun vanGelder, Maaike van derLee, Jan‐Stephan Sanders, Frederike J. Bemelman, Johan W. deFijter, Kathrin Klein, Matthias Schwab, Jesse J. Swen
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13729

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https://doi.org/10.1111/cts.13729

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