Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway

Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway

Abstract Background In this study, we investigated the mechanism of platelet activation in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), as well as the activation of the alternative complement pathway by platelets in AAV. Methods CD62P and platelet-leukocyte a...

Full description

Bibliographic Details
Main Authors: Di Miao, Dan-Yang Li, Min Chen, Ming-Hui Zhao
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Arthritis Research & Therapy
Subjects:
ANCA
Vasculitis
Platelets
Thrombin
Protease-activated receptors
Complement
Online Access:http://link.springer.com/article/10.1186/s13075-017-1458-y

Internet

http://link.springer.com/article/10.1186/s13075-017-1458-y

Similar Items