Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling

Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling

Summary: Glucocorticoid (GC) signaling is essential for mounting a stress response, however, chronic stress or prolonged GC therapy downregulates the GC receptor (GR), leading to GC resistance. Regulatory mechanisms that refine this equilibrium are not well understood. Here, we identify seven lysine...

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Bibliografische gegevens
Hoofdauteurs: Aishwarya Iyer-Bierhoff, Martin Wieczorek, Sina Marielle Peter, Dima Ward, Martin Bens, Sabine Vettorazzi, Karl-Heinz Guehrs, Jan P. Tuckermann, Thorsten Heinzel
Formaat: Artikel
Taal:English
Gepubliceerd in: Elsevier 2024-02-01
Reeks:iScience
Onderwerpen:
Biochemistry
Physiology
Molecular biology
Online toegang:http://www.sciencedirect.com/science/article/pii/S2589004224001640

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224001640

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