Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling

Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling

Summary: Glucocorticoid (GC) signaling is essential for mounting a stress response, however, chronic stress or prolonged GC therapy downregulates the GC receptor (GR), leading to GC resistance. Regulatory mechanisms that refine this equilibrium are not well understood. Here, we identify seven lysine...

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Bibliographic Details
Main Authors: Aishwarya Iyer-Bierhoff, Martin Wieczorek, Sina Marielle Peter, Dima Ward, Martin Bens, Sabine Vettorazzi, Karl-Heinz Guehrs, Jan P. Tuckermann, Thorsten Heinzel
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Biochemistry
Physiology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224001640

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