Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development

Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development

Plasma cells (PCs) and their progenitors plasmablasts (PBs) are essential for the acute and long-term protection of the host against infections by providing vast levels of highly specific antibodies. Several transcription factors, like Blimp1 and Irf4, are already known to be essential for PC and PB...

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Bibliographic Details
Main Authors: Theresa Pinter, Maria Fischer, Markus Schäfer, Michaela Fellner, Julian Jude, Johannes Zuber, Meinrad Busslinger, Miriam Wöhner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
plasmablast
CRISPR/Cas9
sgRNA libraries
plasmablast differentiation
NIPBL
MAU2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.979606/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.979606/full

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