The Two Sweet Sides of Janus Lectin Drive Crosslinking of Liposomes to Cancer Cells and Material Uptake

The Two Sweet Sides of Janus Lectin Drive Crosslinking of Liposomes to Cancer Cells and Material Uptake

A chimeric, bispecific Janus lectin has recently been engineered with different, rationally oriented recognition sites. It can bind simultaneously to sialylated and fucosylated glycoconjugates. Because of its multivalent architecture, this lectin reaches nanomolar avidities for sialic acid and fucos...

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Bibliographic Details
Main Authors: Lina Siukstaite, Francesca Rosato, Anna Mitrovic, Peter Fritz Müller, Katharina Kraus, Simona Notova, Anne Imberty, Winfried Römer
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Toxins
Subjects:
chimeric carbohydrate
protein engineering
hypersialylation
giant unilamellar vesicles
drug delivery
cancer cell targeting
Online Access:https://www.mdpi.com/2072-6651/13/11/792

Internet

https://www.mdpi.com/2072-6651/13/11/792

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