Low-Dose 5-Aza and DZnep Alleviate Acute Graft-Versus-Host Disease With Less Side Effects Through Altering T-Cell Differentiation

Low-Dose 5-Aza and DZnep Alleviate Acute Graft-Versus-Host Disease With Less Side Effects Through Altering T-Cell Differentiation

ObjectivePrevious studies showed that hypomethylating agents (HMAs) could alleviate acute graft-versus-host disease (aGvHD), but affect engraftment after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The combination of two different HMAs in lower doses might overcome this problem....

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Bibliographic Details
Main Authors: Qing Ya Wang, Hui Hui Liu, Yu Jun Dong, Ze Yin Liang, Yue Yin, Wei Liu, Qing Yun Wang, Qian Wang, Yu Hua Sun, Wei Lin Xu, Na Han, Yuan Li, Han Yun Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
acute graft-versus-host disease (aGvHD)
epigenetic
hypomethylation agents
histone modification
mouse model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.780708/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.780708/full

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