Exploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome

Women are disproportionately affected by Alzheimer's disease (AD), yet little is known about sex-specific effects on the development of AD in the Down syndrome (DS) population. DS is caused by a full or partial triplication of chromosome 21, which harbors the amyloid precursor protein (APP) gen...

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Bibliographic Details
Main Authors: Elizabeth J. Andrews, Alessandra C. Martini, Elizabeth Head
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.954999/full