Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88

Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88

Abstract Background Higher-order self-assembly of proteins, or “prion-like” polymerisation, is now emerging as a simple and robust mechanism for signal amplification, in particular within the innate immune system, where the recognition of pathogens or danger-associated molecular patterns needs to tr...

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Bibliographic Details
Main Authors: Ailís O’Carroll, Brieuc Chauvin, James W. P. Brown, Ava Meagher, Joanne Coyle, Jurgen Schill, Akshay Bhumkhar, Dominic J. B. Hunter, Thomas Ve, Bostjan Kobe, Emma Sierecki, Yann Gambin
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Biology
Subjects:
MyD88
Polymerisation
Prion-like
Disease-associate point mutations
Single molecule
Eukaryotic cell-free expression
Online Access:http://link.springer.com/article/10.1186/s12915-018-0611-7

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http://link.springer.com/article/10.1186/s12915-018-0611-7

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