Inhibition of sphingosine 1-phosphate lyase activates human keratinocyte differentiation and attenuates psoriasis in mice

Inhibition of sphingosine 1-phosphate lyase activates human keratinocyte differentiation and attenuates psoriasis in mice

Sphingosine 1-phosphate (S1P) lyase is an intracellular enzyme that catalyzes the irreversible degradation of S1P and has been suggested as a therapeutic target for the treatment of psoriasis vulgaris. Because S1P induces differentiation of keratinocytes, we examined whether modulation of S1P lyase...

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Bibliographic Details
Main Authors: Suwon Jeon, Jaehwi Song, Dongyup Lee, Goon-Tae Kim, Si-Hyun Park, Dong-Yoon Shin, Kyong-Oh Shin, Kyungho Park, Soon-Mi Shim, Tae-Sik Park
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Lipid Research
Subjects:
cell cycle
sphingolipid
psoriasis
cell differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520300134

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http://www.sciencedirect.com/science/article/pii/S0022227520300134

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