Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.

Many viruses encode proteins whose major function is to evade or disable the host T cell response. Nevertheless, most viruses are readily detected by host T cells, and induce relatively strong T cell responses. Herein, we employ transgenic CD4(+) and CD8(+) T cells as sensors to evaluate in vitro an...

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Bibliographic Details
Main Authors: Christopher C Kemball, Stephanie Harkins, Jason K Whitmire, Claudia T Flynn, Ralph Feuer, J Lindsay Whitton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2757675?pdf=render