HPV16 E6/E7 -based mRNA vaccine is therapeutic in mice bearing aggressive HPV-positive lesions

HPV16 E6/E7 -based mRNA vaccine is therapeutic in mice bearing aggressive HPV-positive lesions

HPV (Human papillomavirus) affects 600,000 people worldwide each year. Almost all cervical cancers are associated with a past HPV infection. In particular, the positivity to the high-risk type HPV16 is detected in most of the invasive cervical cancers. FDA has approved prophylactic vaccines that pro...

Full description

Bibliographic Details
Main Authors: Kun Zhou, Olga Yuzhakov, Nouredine Behloul, Dehua Wang, Lakshmi Bhagat, Dafeng Chu, Xinyue Zhang, Xinwei Cheng, Lusheng Fan, Xinyu Huang, Teodelinda Mirabella
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
mRNA
lipid nanoparticles
HPV
therapeutic vaccine
tumors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213285/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213285/full

Similar Items