Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients.

Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients.

Drug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In response to the challenge to rapidly identify treatment options for COV...

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Bibliographic Details
Main Authors: Megan M Sperry, Tomiko T Oskotsky, Ivana Marić, Shruti Kaushal, Takako Takeda, Viktor Horvath, Rani K Powers, Melissa Rodas, Brooke Furlong, Mercy Soong, Pranav Prabhala, Girija Goyal, Kenneth E Carlson, Ronald J Wong, Idit Kosti, Brian L Le, James Logue, Holly Hammond, Matthew Frieman, David K Stevenson, Donald E Ingber, Marina Sirota, Richard Novak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-05-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1011050

Internet

https://doi.org/10.1371/journal.pcbi.1011050

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