Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

Obesity complicates sepsis and increases the mortality of sepsis. We examined the effects of exosomes (from human placenta choriodecidual membrane-derived mesenchymal stem cells, pcMSCs) on preventing sepsis in obesity and the mitigating role of hsa-let-7i-5p microRNA. Obese mice (adult male C57BL/6...

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Bibliographic Details
Main Authors: Chao-Yuan Chang, Kung-Yen Chen, Hung-Jen Shih, Milton Chiang, I-Tao Huang, Yen-Hua Huang, Chun-Jen Huang
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceuticals
Subjects:
obesity
sepsis
liver
exosomes
let-7i
Online Access:https://www.mdpi.com/1424-8247/15/1/36

Internet

https://www.mdpi.com/1424-8247/15/1/36

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