SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration

SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration

Reactive astrogliosis is a common pathological hallmark of CNS injury, infection, and neurodegeneration, where reactive astrocytes can be protective or detrimental to normal brain functions. Currently, the mechanisms regulating neuroprotective astrocytes and the extent of neuroprotection are poorly...

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Bibliographic Details
Main Authors: Surya Chandra Rao Thumu, Monika Jain, Sumitha Soman, Soumen Das, Vijaya Verma, Arnab Nandi, David H Gutmann, Balaji Jayaprakash, Deepak Nair, James P Clement, Swananda Marathe, Narendrakumar Ramanan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
astrocytes
reactive astrocytes
astrogliosis
SRF
serum response factor
neuroprotection
Online Access:https://elifesciences.org/articles/95577

Internet

https://elifesciences.org/articles/95577

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