Silencing of NAC1 Expression Induces Cancer Cells Oxidative Stress in Hypoxia and Potentiates the Therapeutic Activity of Elesclomol

Silencing of NAC1 Expression Induces Cancer Cells Oxidative Stress in Hypoxia and Potentiates the Therapeutic Activity of Elesclomol

In order to survive under conditions of low oxygen, cancer cells can undergo a metabolic switch to glycolysis and suppress mitochondrial respiration in order to reduce oxygen consumption and prevent excessive amounts of reactive oxygen species (ROS) production. Nucleus accumbens-1 (NAC1), a nuclear...

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Bibliographic Details
Main Authors: Yi-Jie Ren, Xiao-Hui Wang, Cheng Ji, Yi-Di Guan, Xian-Jiu Lu, Xian-Rong Liu, Hong-Han Zhang, Ling-Chuan Guo, Qiong-Hua Xu, Wei-Dong Zhu, Zhi-Jun Ming, Jin-Ming Yang, Yan Cheng, Yi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
NAC1
oxidative stress
PDK3
hypoxia
elesclomol
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00804/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00804/full

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