Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico by a Spatial Quantitative Systems Pharmacology Model

Spatial heterogeneity is a hallmark of cancer. Tumor heterogeneity can vary with time and location. The tumor microenvironment (TME) encompasses various cell types and their interactions that impart response to therapies. Therefore, a quantitative evaluation of tumor heterogeneity is crucial for the...

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Bibliographic Details
Main Authors: Mehdi Nikfar, Haoyang Mi, Chang Gong, Holly Kimko, Aleksander S. Popel
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/15/10/2750