Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico by a Spatial Quantitative Systems Pharmacology Model
Spatial heterogeneity is a hallmark of cancer. Tumor heterogeneity can vary with time and location. The tumor microenvironment (TME) encompasses various cell types and their interactions that impart response to therapies. Therefore, a quantitative evaluation of tumor heterogeneity is crucial for the...
Main Authors: | Mehdi Nikfar, Haoyang Mi, Chang Gong, Holly Kimko, Aleksander S. Popel |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-05-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/15/10/2750 |
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