The HR2 polymorphism N140I in the HIV-1 gp41 combined with the HR1 V38A mutation is associated with a less cytopathic phenotype

The HR2 polymorphism N140I in the HIV-1 gp41 combined with the HR1 V38A mutation is associated with a less cytopathic phenotype

<p>Abstract</p> <p>Background</p> <p>Resistance to the fusion inhibitor enfuvirtide (ENF) is achieved by changes in the gp41 subunit of the HIV envelope glycoprotein (Env). Specific ENF-associated mutational pathways correlate with immunological recovery, even after vir...

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Bibliographic Details
Main Authors: Cunyat Francesc, Marfil Silvia, García Elisabet, Svicher Valentina, Pérez-Alvárez Nuria, Curriu Marta, Perno Carlo, Clotet Bonaventura, Blanco Julià, Cabrera Cecilia
Format: Article
Language:English
Published: BMC 2012-02-01
Series:Retrovirology
Subjects:
HIV
gp41
enfuvirtide
single cell death
fusogenicity
Online Access:http://www.retrovirology.com/content/9/1/15

Internet

http://www.retrovirology.com/content/9/1/15

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