A combined spatial score of granzyme B and CD68 surpasses CD8 as an independent prognostic factor in TNM stage II colorectal cancer

A combined spatial score of granzyme B and CD68 surpasses CD8 as an independent prognostic factor in TNM stage II colorectal cancer

Abstract Background Previous assessments of peritumoral inflammatory infiltrate in colorectal cancer (CRC) have focused on the role of CD8+ T lymphocytes. We sought to compare the prognostic value of CD8 with downstream indicators of active immune cell function, specifically granzyme B (GZMB) and CD...

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Bibliographic Details
Main Authors: Luca Noti, José A. Galván, Heather Dawson, Alessandro Lugli, Richard Kirsch, Naziheh Assarzadegan, David Messenger, Philippe Krebs, Martin D. Berger, Inti Zlobec
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Tumour microenvironment
Tumour immune surveillance
Digital pathology
Online Access:https://doi.org/10.1186/s12885-022-10048-x

Internet

https://doi.org/10.1186/s12885-022-10048-x

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