Network Diffusion Model of Progression Predicts Longitudinal Patterns of Atrophy and Metabolism in Alzheimer’s Disease
Alzheimer’s disease pathology (AD) originates in the hippocampus and subsequently spreads to temporal, parietal, and prefrontal association cortices in a relatively stereotyped progression. Current evidence attributes this orderly progression to transneuronal transmission of misfolded proteins along...
Main Authors: | Ashish Raj, Eve LoCastro, Amy Kuceyeski, Duygu Tosun, Norman Relkin, Michael Weiner |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2015-01-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124714010638 |
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