Binding Kinetics of Ruthenium Pyrithione Chemotherapeutic Candidates to Human Serum Proteins Studied by HPLC-ICP-MS

Binding Kinetics of Ruthenium Pyrithione Chemotherapeutic Candidates to Human Serum Proteins Studied by HPLC-ICP-MS

The development of ruthenium-based complexes for cancer treatment requires a variety of pharmacological studies, one of them being a drug’s binding kinetics to serum proteins. In this work, speciation analysis was used to study kinetics of ruthenium-based drug candidates with human serum p...

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Bibliographic Details
Main Authors: Katarina Marković, Radmila Milačič, Stefan Marković, Jerneja Kladnik, Iztok Turel, Janez Ščančar
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
<b>keywords: r</b>uthenium-based chemotherapeutics
drug candidates
pyrithione
kinetics study
human serum
speciation analysis
clc monolithic chromatography
cim protein g and deae disks
uv spectrometry
isotope dilution inductively coupled plasma mass spectrometry
Online Access:https://www.mdpi.com/1420-3049/25/7/1512

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https://www.mdpi.com/1420-3049/25/7/1512

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