Design, synthesis, and biological evaluation of benzenesulfonyl chloride-substituted evodiamine derivatives as potential PGAM1 inhibitors

Design, synthesis, and biological evaluation of benzenesulfonyl chloride-substituted evodiamine derivatives as potential PGAM1 inhibitors

Evodiamine (EVO) is a quinazoline carboline alkaloid isolated from the fruits of the traditional Chinese herb Evodiae fructus. In the present study, we synthesized thirty EVO derivatives (9–38) with various benzenesulfonyl groups by sulfonylation of the amino group of 3-NH-EVO and thirty benzenesulf...

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Bibliographic Details
Main Authors: Binbin Wei, Jingjing Ma, Hui Guo, Yingying Zhang, Weitong Zhang, Wenzhuo Chen, Dongyan Guo, Yuwei Wang, Yuping Tang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Arabian Journal of Chemistry
Subjects:
Benzenesulfonyl chloride
Evodiamine
Phosphoglycerate mutase 1 inhibitor
Structure-activity relationship
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223007578

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http://www.sciencedirect.com/science/article/pii/S1878535223007578

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