Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion1[S]

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion1[S]

Humans and mice lacking angiopoietin-like protein 3 (ANGPTL3) have pan-hypolipidemia. ANGPTL3 inhibits two intravascular lipases, LPL and endothelial lipase, and the low plasma TG and HDL-cholesterol levels in ANGPTL3 deficiency reflect increased activity of these enzymes. The mechanism responsible...

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Bibliographic Details
Main Authors: Yan Wang, Viktoria Gusarova, Serena Banfi, Jesper Gromada, Jonathan C. Cohen, Helen H. Hobbs
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Journal of Lipid Research
Subjects:
cholesterol
dyslipidemias
lipase/endothelial
lipase/lipoprotein
angiopoietin-like protein 3
very low density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520355498

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http://www.sciencedirect.com/science/article/pii/S0022227520355498

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