Pancreatic Cancer Patient-Derived Organoid Platforms: A Clinical Tool to Study Cell- and Non-Cell-Autonomous Mechanisms of Treatment Response

Pancreatic Cancer Patient-Derived Organoid Platforms: A Clinical Tool to Study Cell- and Non-Cell-Autonomous Mechanisms of Treatment Response

For many years, cell lines and animal models have been essential to improve our understanding of the basis of cell metabolism, signaling, and genetics. They also provided an essential boost to cancer drug discovery. Nevertheless, these model systems failed to reproduce the tumor heterogeneity and th...

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Bibliographic Details
Main Authors: Geny Piro, Antonio Agostini, Alberto Larghi, Giuseppe Quero, Carmine Carbone, Annachiara Esposito, Gianenrico Rizzatti, Fabia Attili, Sergio Alfieri, Guido Costamagna, Giampaolo Tortora
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Medicine
Subjects:
patient derived organoid
pancreatic cancer
precision medicine
EUS-guided sampling
tumor-stroma heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.793144/full

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https://www.frontiersin.org/articles/10.3389/fmed.2021.793144/full

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