Adenoviruses vectored hepatitis C virus vaccine cocktails induce broadly specific immune responses against multi-genotypic HCV in mice

Adenoviruses vectored hepatitis C virus vaccine cocktails induce broadly specific immune responses against multi-genotypic HCV in mice

Background: Hepatitis C virus (HCV) vaccines are an urgent need to prevent hepatitis C and its further progression of hepatocellular carcinoma. Since the promising T cell based chimpanzee adenovirus and modified vaccinia virus Ankara vectorial HCV vaccines were failed in clinical phase II trial, the...

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Bibliographic Details
Main Authors: Shengxue Luo, Panli Zhang, Yilin Wang, Yunzhu Huang, Xiaorui Ma, Qitao Deng, Peng Zou, Cong Wang, Ling Zhang, Yiping Li, Yongshui Fu, Tingting Li, Chengyao Li
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
HCV vaccine cocktails
Envelope proteins
Nonstructural proteins
Genotypes-1b/6a
Adenovirus vectors
Prime-boost regimens
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016992

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http://www.sciencedirect.com/science/article/pii/S0753332223016992

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