DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation

DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation

Methylation of histone H3 at lysine 79 (H3K79) is conserved from yeast to humans and is accomplished by Dot1 (disruptor of telomeric silencing-1) methyltransferases. The C. elegans enzyme DOT-1.1 and its interacting partners are similar to the mammalian DOT1L (Dot1-like) complex. The C. elegans DOT-...

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Bibliographic Details
Main Authors: Thomas Liontis, Karisma Verma, Alla Grishok
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:BBA Advances
Subjects:
H3K79 methylation
DOT1L, C. elegans
RNAi
Small RNA
CED-3
Online Access:http://www.sciencedirect.com/science/article/pii/S2667160323000091

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http://www.sciencedirect.com/science/article/pii/S2667160323000091

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