Network diffusion model predicts neurodegeneration in limb-onset Amyotrophic Lateral Sclerosis.

Network diffusion model predicts neurodegeneration in limb-onset Amyotrophic Lateral Sclerosis.

<h4>Objective</h4>Emerging evidences suggest that the trans-neural propagation of phosphorylated 43-kDa transactive response DNA-binding protein (pTDP-43) contributes to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). We investigated whether Network Diffusion Model (NDM), a bio...

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Bibliographic Details
Main Authors: Anjan Bhattarai, Zhaolin Chen, Phyllis Chua, Paul Talman, Susan Mathers, Caron Chapman, James Howe, C M Sarah Lee, Yenni Lie, Govinda R Poudel, Gary F Egan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0272736

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https://doi.org/10.1371/journal.pone.0272736

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