IRF8 deficiency-induced myeloid-derived suppressor cell promote immune evasion in lung adenocarcinoma

IRF8 deficiency-induced myeloid-derived suppressor cell promote immune evasion in lung adenocarcinoma

Abstract Background Patients with lung adenocarcinoma (LUAD) have a low response rate to immune checkpoint blockade. It is highly important to explore the tumor immune escape mechanism of LUAD patients and expand the population of patients who may benefit from immunotherapy. Methods Based on 954 bul...

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Bibliographic Details
Main Authors: Zhen Gao, Shang Liu, Han Xiao, Meng Li, Wan-gang Ren, Lin Xu, Zhong-min Peng
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Journal of Translational Medicine
Subjects:
Lung adenocarcinoma
MDSCs
IRF8
Tumor microenvironment
Immune escape
Online Access:https://doi.org/10.1186/s12967-024-05519-7

Internet

https://doi.org/10.1186/s12967-024-05519-7

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