Novel therapeutic agents for HbF induction: a new era for treatment of β thalassemia?

Novel therapeutic agents for HbF induction: a new era for treatment of β thalassemia?

<p>Fetal globin is endogenous, normally integrated in hematopoietic stem cells in all humans, and available for reactivation. Inducing expression of fetal globin (g-globin) gene expression to 60-70% of a globin synthesis produces β-thalassemia trait globin synthetic ratios, and has be...

Full description

Bibliographic Details
Main Author:	S.P. Perrine
Format:	Article
Language:	English
Published:	MDPI AG 2011-12-01
Series:	Thalassemia Reports
Subjects:	thalassemia, erythropoiesis, fetal globin, therapeutics, quantitative trait loci.
Online Access:	http://www.pagepressjournals.org/index.php/thal/article/view/297

Similar Items

Closed relationship of βE-allele and high HbF associated cis-loci: Case studies in Thai HbE/ β-thalassemia families
by: Lamplimas Tangpan, et al.
Published: (2015-05-01)

Therapeutic Relevance of Inducing Autophagy in β-Thalassemia
by: Roberto Gambari, et al.
Published: (2024-05-01)

Periferik Kanında %100 HbF Bulunan Talasemi İntermedia Olgusu
by: Ayşegül Uğur Kurtoğlu, et al.
Published: (2021-06-01)

Pharmacological Induction of Fetal Hemoglobin in β-Thalassemia and Sickle Cell Disease: An Updated Perspective
by: Rayan Bou-Fakhredin, et al.
Published: (2022-06-01)

Genetic modifications of EGLN1 reactivate HbF production in β0-thalassemia/HbE
by: Varit Jan-ngam, et al.
Published: (2024-09-01)

Molecular identification of Sicilian (dß)º-thalassemia associated with ß-thalassemia and hemoglobin S in Brazil
by: Andrade T.G. de, et al.
Published: (2002-01-01)

Challenges in the Diagnosis of Beta-thalassemia Syndrome: The Importance of Molecular Diagnosis
by: Zefarina Zulkafli, et al.
Published: (2022-01-01)

The Spectrum of β -thalassemia Mutations in Isfahan Province of Iran
by: P Derakhshandeh-Peykar, et al.
Published: (2008-06-01)

Molecular Analysis of HS-111 and 3`HS1 Variations in β-Thalassemia Intermedia Patients with High Levels of HbF
by: Mohammad Hamid, et al.
Published: (2010-01-01)

Induction of HBF
by: Mehran Karimi, et al.
Published: (2013-03-01)

Molecular Analysis of β-Globin Mutations Among β-Thalassemia Patients in Hamadan
by: Fatemeh Ramezani, et al.
Published: (2021-06-01)

Evaluation of common mutations in β-thalassemia patients in Iranian populations using SNaPshot method
by: Mehrzad S, et al.
Published: (2020-07-01)

HbE and HbF levels in HbE/βO-thalassemia are heterogeneous
by: Thanusak Tatu, et al.
Published: (2011-01-01)

Polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis
by: Afaq A. Khan, et al.
Published: (2023-02-01)

The correlation between ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia
by: Siriyakorn Chansai, et al.
Published: (2022-06-01)

Evaluation of the level of liver enzymes and its relationship with ferritin and the frequency of blood transfusion in patients with thalassemia
by: Khadije Saravani, et al.
Published: (2024-06-01)

Thalassemia, a human blood disorder
by: F. Shafique, et al.
Published: (2021-09-01)

Combined approaches for increasing fetal hemoglobin (HbF) and de novo production of adult hemoglobin (HbA) in erythroid cells from β-thalassemia patients: treatment with HbF inducers and CRISPR-Cas9 based genome editing
by: Alessia Finotti, et al.
Published: (2023-07-01)

The Optimized γ-Globin Lentiviral Vector GGHI-mB-3D Leads to Nearly Therapeutic HbF Levels In Vitro in CD34<sup>+</sup> Cells from Sickle Cell Disease Patients
by: Ekati Drakopoulou, et al.
Published: (2022-12-01)

The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies
by: Roberto Gambari, et al.
Published: (2023-09-01)

Distribution of β-Globin Gene Mutations in Thalassemia Minor Population of Kerman Province, Iran
by: N Saleh-Gohari, et al.
Published: (2010-06-01)

Distribution of β-Globin Gene Mutations in Thalassemia Minor Population of Kerman Province, Iran
by: MR Bazrafshani, et al.
Published: (2010-06-01)

beta-thalassemia intermedia in a Brazilian patient with - 101(C > T) and codon 39 (C > T) mutations
by: Sylvia Morais de Sousa, et al.

Primitive and definitive erythropoiesis in mammals
by: James ePalis
Published: (2014-01-01)

Current and future alternative therapies for beta-thalassemia major
by: Edouard de Dreuzy, et al.
Published: (2016-02-01)

Comprehensive analysis of a-and b-thalassemia genotypes and hematologic phenotypes
by: Heng Wang, et al.
Published: (2025-01-01)

miRNA Expression Associated with HbF in Saudi Sickle Cell Anemia
by: Cyril Cyrus, et al.
Published: (2022-10-01)

Haplotype Analysis in Carriers of β-Globin Gene Mutation Facil-itates Genetic Counseling in β-Thalassemia: A Cross-Sectional Study in Kerman Province, Iran
by: Nasrollah SALEH-GOHARI, et al.
Published: (2020-04-01)

The incidence of alpha-thalassemia in Setif, Algeria
by: Ayşenur Öztürk, et al.
Published: (2010-12-01)

β globin mutations in Turkish, Northern Iraqi and Albanian patients with β thalassemia major
by: Veysel Sabri Hancer, et al.
Published: (2018-06-01)

Novel Therapeutic Advances in β-Thalassemia
by: Alexandros Makis, et al.
Published: (2021-06-01)

Beta globin gene cluster haplotypes of the beta thalassemia mutations observed in the Denizli province of Turkey
by: Anzel Bahadır, et al.
Published: (2009-09-01)

CRISPR Gene Therapy: A Promising One-Time Therapeutic Approach for Transfusion-Dependent β-Thalassemia—CRISPR-Cas9 Gene Editing for β-Thalassemia
by: Udani Gamage, et al.
Published: (2023-02-01)

Thalassemia intermedia as a result of heterozygosis for ß0-thalassemia and <FONT FACE=Symbol>aaa</FONT>anti-3.7/<FONT FACE=Symbol>aa</FONT> genotype in a Brazilian patient
by: E.M. Kimura, et al.
Published: (2003-06-01)

Delta-Globin Gene Expression Is Enhanced in vivo by Interferon Type I
by: Maria Francesca Manchinu, et al.
Published: (2020-05-01)

Alpha and beta-Thalassemia mutations in Hubei area of China
by: Yaowu Zhu, et al.
Published: (2020-01-01)

Polymorphisms at rs368698783 and rs7482144 loci in the promoter region of the HBG gene are associated with HbF expression
by: DENG Ling, LONG Lan, YANG Yang, JIN Chanchan, LI Suyun, FENG Na, HE Jing
Published: (2023-02-01)

The Spectrum of β -Thalassemia Mutations in Isfahan Province of Iran
by: P Derakhshandeh-Peykar, et al.
Published: (2008-07-01)

Alpha‐globin gene triplication and its effect in beta‐thalassemia carrier, sickle cell trait, and healthy individual
by: Mohammad Hamid, et al.
Published: (2021-08-01)

Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia
by: Xiuqin Bao, et al.
Published: (2024-01-01)