High frequencies of alpha common cold coronavirus/SARS-CoV-2 cross-reactive functional CD4+ and CD8+ memory T cells are associated with protection from symptomatic and fatal SARS-CoV-2 infections in unvaccinated COVID-19 patients

High frequencies of alpha common cold coronavirus/SARS-CoV-2 cross-reactive functional CD4+ and CD8+ memory T cells are associated with protection from symptomatic and fatal SARS-CoV-2 infections in unvaccinated COVID-19 patients

BackgroundCross-reactive SARS-CoV-2-specific memory CD4+ and CD8+ T cells are present in up to 50% of unexposed, pre-pandemic, healthy individuals (UPPHIs). However, the characteristics of cross-reactive memory CD4+ and CD8+ T cells associated with subsequent protection of asymptomatic coronavirus d...

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Bibliographic Details
Main Authors: Pierre-Gregoire Coulon, Swayam Prakash, Nisha R. Dhanushkodi, Ruchi Srivastava, Latifa Zayou, Delia F. Tifrea, Robert A. Edwards, Cesar J. Figueroa, Sebastian D. Schubl, Lanny Hsieh, Anthony B. Nesburn, Baruch D. Kuppermann, Elmostafa Bahraoui, Hawa Vahed, Daniel Gil, Trevor M. Jones, Jeffrey B. Ulmer, Lbachir BenMohamed
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
symptomatic
asymptomatic
COVID-19
common cold coronavirus
CD4 + T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1343716/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1343716/full

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