Periosteal CD68+F4/80+ Macrophages Are Mechanosensitive for Cortical Bone Formation by Secretion and Activation of TGF‐β1

Periosteal CD68+F4/80+ Macrophages Are Mechanosensitive for Cortical Bone Formation by Secretion and Activation of TGF‐β1

Abstract Mechanical force regulates bone density, modeling, and homeostasis. Substantial periosteal bone formation is generated by external mechanical stimuli, yet its mechanism is poorly understood. Here, it is shown that myeloid‐lineage cells differentiate into subgroups and regulate periosteal bo...

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Bibliographic Details
Main Authors: Ruoxian Deng, Changwei Li, Xiao Wang, Leilei Chang, Shuangfei Ni, Weixin Zhang, Peng Xue, Dayu Pan, Mei Wan, Lianfu Deng, Xu Cao
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Advanced Science
Subjects:
cortical bone formation
macrophage
mechanical loading
periosteum
Online Access:https://doi.org/10.1002/advs.202103343

Internet

https://doi.org/10.1002/advs.202103343

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