Activation of Membrane Estrogen Receptors Attenuates NOP-Mediated Tactile Antihypersensitivity in a Rodent Model of Neuropathic Pain

Activation of Membrane Estrogen Receptors Attenuates NOP-Mediated Tactile Antihypersensitivity in a Rodent Model of Neuropathic Pain

Women manifest a higher prevalence of several chronic pain disorders compared to men. We demonstrated earlier that estrogen rapidly attenuates nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP)-mediated thermal antinociception through the activation of membrane estrogen receptors (mERs). However,...

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Bibliographic Details
Main Authors: Danyeal M. Wright, Keri M. Small, Subodh Nag, Sukhbir S. Mokha
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Brain Sciences
Subjects:
nociceptin/orphanin FQ receptor
neuropathic pain
spinal cord
spared nerve injury
analgesia
Online Access:https://www.mdpi.com/2076-3425/9/6/147

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https://www.mdpi.com/2076-3425/9/6/147

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