Simultaneous HPLC Determination of Clindamycin Phosphate, Tretinoin, and Preservatives in Gel Dosage Form Using a Novel Stability-Indicating Method

Simultaneous HPLC Determination of Clindamycin Phosphate, Tretinoin, and Preservatives in Gel Dosage Form Using a Novel Stability-Indicating Method

The most well-known, effective medicines for acne therapy are clindamycin phosphate and tretinoin. For the first time, we have developed and validated a reversed-phase HPLC stability-indicating technique for the detection of clindamycin phosphate (CLP), tretinoin (TRN), and two preservatives, methyl...

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Bibliographic Details
Main Authors: Sadaf Sarfraz, Shahid Hussain, Mohsin Javed, Ali Raza, Shahid Iqbal, Hamad Alrbyawi, Samar O. Aljazzar, Eslam B. Elkaeed, Hamoud H. Somaily, Rami Adel Pashameah, Eman Alzahrani, Abd-ElAziem Farouk
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Inorganics
Subjects:
RP-HPLC
clindamycin phosphate
tretinoin
imidazolidinyl urea
methylparaben
method development and validation
Online Access:https://www.mdpi.com/2304-6740/10/10/168

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https://www.mdpi.com/2304-6740/10/10/168

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