COX-2 Inhibition by Diclofenac Is Associated With Decreased Apoptosis and Lesion Area After Experimental Focal Penetrating Traumatic Brain Injury in Rats

COX-2 Inhibition by Diclofenac Is Associated With Decreased Apoptosis and Lesion Area After Experimental Focal Penetrating Traumatic Brain Injury in Rats

Traumatic brain injury (TBI) is followed by a secondary inflammation in the brain. The inflammatory response includes prostanoid synthesis by the inducible enzyme cyclooxygenase-2 (COX-2). Inhibition of COX-2 is associated with improved functional outcome in experimental TBI models, although central...

Full description

Bibliographic Details
Main Authors: Kayvan Dehlaghi Jadid, Johan Davidsson, Erik Lidin, Anders Hånell, Maria Angéria, Tiit Mathiesen, Mårten Risling, Mattias Günther
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neurology
Subjects:
cyklooxygenase-2
diclofenac
focal penetrating TBI
NSAID
traumatic brain injury
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00811/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2019.00811/full

Similar Items