Multiple ciliary localization signals control INPP5E ciliary targeting

Multiple ciliary localization signals control INPP5E ciliary targeting

Primary cilia are sensory membrane protrusions whose dysfunction causes ciliopathies. INPP5E is a ciliary phosphoinositide phosphatase mutated in ciliopathies like Joubert syndrome. INPP5E regulates numerous ciliary functions, but how it accumulates in cilia remains poorly understood. Herein, we sho...

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Bibliographic Details
Main Authors: Dario Cilleros-Rodriguez, Raquel Martin-Morales, Pablo Barbeito, Abhijit Deb Roy, Abdelhalim Loukil, Belen Sierra-Rodero, Gonzalo Herranz, Olatz Pampliega, Modesto Redrejo-Rodriguez, Sarah C Goetz, Manuel Izquierdo, Takanari Inoue, Francesc R Garcia-Gonzalo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
cilia
ciliopathies
Joubert syndrome
INPP5E
phosphoinositides
phosphatase
Online Access:https://elifesciences.org/articles/78383

Internet

https://elifesciences.org/articles/78383

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